CD8A and neoplasm: For instance, patients diagnosed with HPV-positive oropharyngeal carcinoma often exhibited a high density of CD8 + cells, as illustrated in Fig. 2C. In addition, our analysis revealed that both CD3 + and CD8 + cell densities at the tumor center and the invasion front were notably higher in patients who did not experience recurrence compared to those who did (Supplementary Fig. S8).