Another defining feature of CSCs is their high ALDH activity, which plays a crucial role in oxidative stress resistance and the detoxification of cytotoxic agents.342,343 ALDH catalyzes the oxidation of aldehydes into carboxylic acids, preventing ROS-induced apoptosis and enhancing CSC survival.344 High ALDH activity has been identified as a CSC marker in breast, ovarian, lung, and colorectal cancers, where it is correlated with poor prognosis and therapy resistance.345,346 ALDH inhibitors, such as disulfiram and all-trans RA, have been investigated as potential CSC-targeting agents. The gene discussed is LDHA; the disease is colorectal cancer.