GLS and cancer: Glutamate further fuels the TCA cycle and supports the synthesis of GSH, a key antioxidant that protects CSCs from oxidative stress-induced apoptosis.315 Since CSCs strongly depend on glutamine metabolism, GLS inhibitors such as CB-839 are currently being investigated in clinical trials for various cancers (NCT02771626, NCT03057600, and NCT03163667), with potential implications for CSC-targeted therapy.