Moreover, pretreatment of cancer cells with vesicles released following P2X7 blockade (AZ-VS) was able to decrease the level of Foxp3, hinting at an additional mechanism by which P2X7 receptor might be influencing CRC dissemination by shaping Tregs-mediated and other immune responses leading to CRC progression [68, 69]. This evidence concerns the gene P2RX7 and cancer.