P2RX7 and colorectal carcinoma: Finally, when we performed similar experiments with HCT116 human CRC cells in nude mice, we did not measure any effect of P2X7 and A2A blockade alone or in combination, either in the subcutaneous (Fig. 6D, E) or intravenous model (Fig. 6F, G), further suggesting strong involvement of the immune response in the mechanism of action of the drugs.