P2RX7 and colorectal carcinoma: Moreover, we extended these findings to a live model of metastatic carcinogenesis, showing not only increased dissemination and engraftment in the lungs of CRC cells pre-treated with P2X7-VS and intravenously injected in mice, but that this preconditioning even enhanced the levels of particles measured in mice plasma 14 days after the cell inoculum (Fig. 2F).