To further characterize the cellular target of in vivo DSF treatment, we generated GSDMD-knockout MC38 cells (Supplemental Figure 1K) and showed that, in contrast to the diminished tumor-promoting effect of DSF treatment in the Gsdmd–/– mice, DSF treatment retained the ability to promote the growth of GSDMD-deficient MC38 tumors in WT mice (Figure 1I). The gene discussed is GSDMD; the disease is neoplasm.