NF1 and Spinal neurofibroma: The clinical features of some patients suggested an alternative form of NF1, called familial spinal neurofibromatosis (MIM #162210)36 due to the presence of numerous spinal neurofibromas, with or without other features suggestive of NF1; 12 out of 14 patients carrying missense variants of p.Gly848 had spinal neurofibromas, and a much lower proportion of skin manifestations such as TCLs, frecklings or cNFs was observed for this codon compared with other missense variants in this 844–848 region.