PRODH and 22q11.2 deletion syndrome: This support can help mitigate some of the genetic challenges faced by individuals with 22q11DS, such as those associated with the COMT gene, which is linked to cognitive control and executive function deficits (Armando et al. 2012; Satterfield et al. 2018), and the PRODH gene, which is associated with impairments in working memory and cognitive flexibility (Li et al. 2008).