PRRX1 and neoplasm: To further refine the list of low-risk fibroblast genes and capture those with potential functional tumor-suppressive properties, we focused on genes enriched in the PRRX1low fibroblast group compared with the PRRX1high group, since PRRX1 is a master TF implicated in tumor-promoting CAF phenotypes (Lee et al., 2022, Yeo et al., 2018).