ISLR and neoplasm: In agreement with the recent study by Tew et al, Mizutani and colleagues observed that Meflin-related tumor-inhibitory effects were linked to collagen deposition, as tumors growing in Meflin-knockout mice showed straighter and wider collagen structures as compared with tumors in wild-type mice (Mizutani et al., 2019, Tew et al., 2019).