CLEC7A and nervous system disorder: Microglia are resident macrophages of the brain and constitute thefirst line of immune defense in the CNS. These cells play roles during development and adulthood, acquiringdifferent phenotypes in response to environmental signals., Microglia are dynamic and capable of morphological changes in ashort time frame. Due to this functionality,microglia are key players in brain injury and disease. In this context, DAM has become a major researchfocus for understanding the pathophysiology of neurological disorders.Cumulative evidence suggests a link between DAM and Dectin-1 in CNSdiseases.