CLEC7A and major depressive disorder: In contrast,despite its anti-inflammatory effect in depression,recent studies have linked Dectin-1 to the development of psychosocialstress. According to Zhu et al. (2023),Dectin-1 receptor signaling modulates behavioral vulnerability tochronic social stress via γδ T cells. Dectin-1 mediates the signaling of colonic interleukin-17-producingγδ T cells (γδ17 T cells) and their accumulationin the meninges, which results in stress-susceptible behavior.