Previous studies have identified the antidepressantpotential of Dectin-1 through its activation by β-1,3-linkedglucan., The observed antidepressant effect was robustand long-lasting due to increased receptor levels and the activationof the Dectin-1/AMPA signaling pathway. Binding to Dectin-1 can lead to activation of the Syk/NFκBsignaling pathway and immune system regulation. Similar results also identified this pathway in the treatmentof depression. Here, CLEC7A is linked to depressive symptom measurement.