Major depressive disorder is also considereda microglial disease.Structural and functional impairment of microglia caused by intenseinflammatory activation or cellular senescence can lead to depressionand deficits associated with neural plasticity and neurogenesis. Furthermore, the microglia/Dectin-1 associationis present in psychiatric disorders such as depression. Most studies evaluating the antidepressantpotential of Dectin-1 involve microglial populations and anti-inflammatoryeffects. This evidence concerns the gene CLEC7A and major depressive disorder.