Li et al. (2021) identifiedthe rapid and robust antidepressant potential of Dectin-1 throughactivation by polysaccharide(GLP). Treatment with GLP attenuatedthe expression of potential markers of depressive disorder such asIL-1β and TNF-α and increased the expression of the anti-inflammatorycytokine IL-10 and brain-derived neurotrophic factor (BDNF) in thehippocampus of mice. Receptor levelssignificantly increased following GLP treatment, and Dectin-1 receptorblockers such as laminarin inhibited GLP’s antidepressant effect. This evidence concerns the gene IL10 and depressive disorder.