CRP and chronic obstructive pulmonary disease: Trait enrichment analysis confirmed that SCT-associated CpGs were significantly enriched for C-reactive protein (CRP) levels (FDR=2.6×10−15) and GZMK protein levels (FDR=8.9×10−13), along with BMI (FDR=3.3×10−7), age (FDR=0.002), clear cell renal carcinoma (FDR=0.005) [81], atopy (FDR=0.019), tissue (FDR=0.019), maternal BMI (FDR=0.021) and incident COPD (FDR=0.038) (Figure 3(b)).