COL5A3 and viral infectious disease: It is worth noting that genes relating to innate immune response to viral infection (e.g., DHX58, MX1, IFITM-like), cell structure integrity (e.g., ANGPTL3, ANGPTL4, ELFN2, COL5A3) and transcription factors (e.g., TUB) remained upregulated throughout the acute phase of infection (1–6 dpi) (Fig 11A).