It is worth noting that genes relating to innate immune response to viral infection (e.g., DHX58, MX1, IFITM-like), cell structure integrity (e.g., ANGPTL3, ANGPTL4, ELFN2, COL5A3) and transcription factors (e.g., TUB) remained upregulated throughout the acute phase of infection (1–6 dpi) (Fig 11A). This evidence concerns the gene ANGPTL4 and viral infectious disease.