TMEM45B and infection: The most common genes in the top 10 most significant DEGs for the response contrasts, which represent comparisons between the populations based on the change in expression over time and therefore detect differences in gene expression between the populations in response to infection [34], included genes which are involved in in inflammation and immunity such as the olfactomedin 4 gene (OLFM4) and the transmembrane protein 45B gene (TMEM45B) [115,116].