In the pancreas cancer subnetwork, key TFS such as APC (encodes APC), RB1 (encodes pRb), DNMT3A, TP53 (p53), MYC, CTNNB1 (Beta Catenin-1) and SMAD4 (Smad4) contribute to mutation pairs. Here, SMAD4 is linked to pancreatic neoplasm.