In the pancreas cancer subnetwork, key TFS such as APC (encodes APC), RB1 (encodes pRb), DNMT3A, TP53 (p53), MYC, CTNNB1 (Beta Catenin-1) and SMAD4 (Smad4) contribute to mutation pairs. The gene discussed is DNMT3A; the disease is pancreatic neoplasm.