NLRP3 and diabetes mellitus: In diabetic retinopathy, hyperglycemiamay initiate NLRP3 inflammasome activation. To understand the role of hyperglycemia in NLRP3 inflammasome activationin diabetes, we exposed human retinal pigment epithelial cells (ARPE-19)to hyperglycemic conditions by treating them with 30 and 50 mM d-glucose and compared them with normoglycemic control ARPE-19cells.