Activation of theNLR-family pyrin domain-containing 3 (NLRP3)inflammasome has been associated with diabetic retinopathy progression.We have synthesized a highly sensitive molecular imaging probe, InflammaProbe-2,as an early detection diagnostic tool for the in vivo molecular imagingof NLRP3 inflammasomes in living diabetic retina. The gene discussed is NLRP3; the disease is diabetic retinopathy.