We have furtherdeveloped InflammaProbe-2 as a sensitive molecular imaging probe todetect only activated NLRP3 inflammasomes in diabetic retinopathy.Mechanistically, InflammaProbe-1 is a derivative of CY09, which possiblybinds to the ATP-binding site of the NACHT domain, and thus InflammaProbe-1 could widely detect both NLRP3and its activated inflammasomes. This evidence concerns the gene NLRP3 and diabetic retinopathy.