PRDX3 and osteoarthritis: Tan et al36 showed that the Sirt3/Prdx3 pathway alleviates mitochondrial dysfunction caused by hypoxia/reoxygenation in cardiomyocytes.36 However, this experiment demonstrated that in the osteoarthritis model, PRDX3 induced SIRT3 expression to control ROS accumulation and mitochondria-dependent ferroptosis.