Ferroptosis, which is iron-dependent cell death, is a type of programmed cell death caused by excessive lipid peroxidation accumulation resulting in membrane rupture.34 GPX4 is a glutathione-regulated lipid repair enzyme that inhibits ferroptosis by reducing ROS.24 Currently, PRDX3 has been shown to suppress ROS accumulation and mitochondria-dependent ferroptosis in both the in vitro model and the mouse model of osteoarthritis. This evidence concerns the gene GPX4 and osteoarthritis.