This article provides an overview of m6A from 3 aspects: N6 methyladenine (m6A) methyltransferase, m6A demethylase, and m6A reading protein.37 It also summarizes the role of m6A RNA methylation modification in the pathogenesis of rheumatoid arthritis, osteoarthritis, and systemic lupus erythematosus.38,39 In the model of osteoarthritis cartilage injury, METTL3-mediated m6A modification reduces PRDX3 mRNA stability. The gene discussed is PRDX3; the disease is osteoarthritis.