BRAF and Familial adenomatous polyposis: BRAF p.V600E (50%) or KRAS (p.G12V/D, 40%) mutations were present in 90% of HPs, with one other HP carrying APC p.R213* (rs587781392) which has been reported in the ClinVar database to be associated with familial adenomatous polyposis and APC-associated cancers (32).