For example, a 3-mm TA harbored one of the highest MB of 6.45, with pathogenic mutational defects in numerous colorectal cancer driver genes (e.g., APC, SOX9, TCF7L2, ASXL1, ERBB3, MAP2K1, and PTPRS, Supplementary Table S6). Here, MAP2K1 is linked to colorectal cancer.