PPARA and nervous system disorder: Likewise, the AMPK protein is currently implicated in the pathophysiology of different processes related to neurological diseases, especially in pathways related to mammalian target of rapamycin (mTOR) and in the regulation of autophagy mechanisms, modulating short-term metabolism cellular enzymes in the cholesterol and fatty acid biosynthesis pathways, and pathways related to mitochondrial biogenesis through the peroxisome proliferator-activated receptor (PPAR) and PPAR coactivator-1 alpha (PGC1alpha) [24].