SQSTM1 and neurodegenerative disease: Previous studies have also demonstrated, through protein interaction network analysis, the pathophysiological correlation of interaction with the sequestosome 1 (SQSTM1) protein [22], which is well-correlated with the pathophysiology of different systemic degenerative and neurodegenerative diseases involving multisystemic proteinopathies, such as frontotemporal dementia, MND/ALS, Paget disease of the bone, and myopathy [1,2].