Finally, the importance of HSPs for the viability and functionality of skeletal muscle cells is further highlighted by the finding that genetic mutations in several HSPs, such as HSPB1, HSPB3, HSPB5, HSPB8, HSP40s (DNAJB4 and DNAJB6) and the HSP70 co-chaperone BAG3, are associated with myopathies and neuromuscular diseases in humans [25,26,27,28,29,30,31,32]. Here, HSPB8 is linked to myopathy.