Consistent with this idea, reduced mitochondrial biogenesis via the suppression of Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1α) is an underlying cause of poor differentiation and maturation/myogenesis of muscle regeneration in atrophic diseases such as Facioscapulohumeral muscular dystrophy (FSHD) [172] and cancer cachexia [173]. The gene discussed is PPARGC1A; the disease is facioscapulohumeral muscular dystrophy.