AFG3L2 and spastic ataxia: It is worth noting that mitochondrial dysfunction has also been identified in other forms of Spinocerebellar Ataxia and spastic ataxias, including Friedreich’s ataxia (FXN), SCA type 28 (AFG3L2), and Autosomal Recessive Spastic Ataxia type 4 (MTPAP) [28,32].