Variants such as rs8192673 in the Growth Factor Receptor Bound Protein 14 gene (GRB14), rs699 in the Angiotensinogen gene (AGT) and rs5370 in the Endothelin 1 gene (EDN1), on the other hand, are associated with chronic degenerative diseases like type 2 diabetes (T2D), essential hypertension (HT) and obesity (Table 2). The gene discussed is EDN1; the disease is obesity due to melanocortin 4 receptor deficiency.