In univariate analysis, these variables were: parotidomegaly (p=0.039), keratoconjunctivitis sicca (p=0.021), Raynaud’s phenomenon (p=0.042), splenomegaly (p=0.034), elevated ESR (p=0.039), leukopenia (p=0.036), positive anti-Ro/SSA antibodies (p=0.03), double positivity for anti-Ro/SSA and anti-La/SSB (p=0.022), positive anti-ENA antibodies (p=0.02), positive RF (p=0.011), positive ANA (p=0.008), polyclonal hypergammaglobulinemia (p=0.032), elevated IgG levels (p=0.04), pathological Schirmer’s test (p=0.018) and decreased UWS flow rate (p=0.001). The gene discussed is CALR; the disease is dry eye syndrome.