The first description of NLRP3-associated autoinflammatory diseases draws several similarities to our present case series where three children presented with a pattern of episodic skin rash, fever, and chronic aseptic meningitis associated with intellectual disability.5 Twenty years prior, dermatologists had identified an autosomal dominant disease with urticaria, deafness, and amyloidosis.4 This evidence concerns the gene NLRP3 and Intellectual disability.