NLRP3 and amyloidosis: The first description of NLRP3-associated autoinflammatory diseases draws several similarities to our present case series where three children presented with a pattern of episodic skin rash, fever, and chronic aseptic meningitis associated with intellectual disability.5 Twenty years prior, dermatologists had identified an autosomal dominant disease with urticaria, deafness, and amyloidosis.4