This spectrum encompasses three autosomal dominant diseases caused by heterozygous gain of function mutations in the NLRP3 gene, including familial cold autoinflammatory syndrome (FCAS, mild phenotype), Muckle-Wells syndrome (MWS, Intermediate phenotype), and in its most severe form; neonatal-onset multisystem inflammatory disease (NOMID). Here, NLRP3 is linked to Muckle-Wells syndrome.