The findings of our study align with the existing literature, reinforcing its striking significance despite the small size of the current series.12,18,28,35–41 Moreover, in our group, anti-TIF1γ(+) patients appeared to have significantly more active skin disease, as seen by the markedly higher CDASI score comparing to negative cases not only among patients with skin involvement (DM plus some ARS plus some OM cases) but also in the pure DM subgroup itself. This evidence concerns the gene TRIM33 and ocular melanoma.