The proinflammatory pathway mediated by IL-6 starts with the interaction of the cytokine with its receptor, which subsequently leads to the formation of a complex of IL-6, IL-6R, and two transmembrane glycoproteins, enabling the activation of Janus kinases (JAKs), leading to the activation of transcription 3 (STAT-3), a molecule that drives a cascade of events that elicit the expression of proinflammatory genes, contributing to the pathogenesis of RA.22,26,27. Here, IL6R is linked to rheumatoid arthritis.