In this study, we demonstrated that autologous infusion of AVIP therapeutic vaccine combined with ART elicited robust SIV‐specific T cell immune responses, prevented a rapid decline in the CD4/CD8 ratio, reduced CD8+ T cell overactivation, accelerated viral suppression, and delayed post‐ART viral rebound and AIDS progression in acute SIV‐infected macaques. This evidence concerns the gene CD4 and AIDS.