Through direct modulation of immune response or inflammatory processes, SHP2 may function as a critical regulator of immune cell‐mediated inflammation [35] and has been implicated in gastrointestinal inflammation, neuroinflammation, liver inflammation, lung inflammation, as well as many autoimmune diseases including psoriasis, diabetes, ankylosing spondylitis, and so forth [34, 36, 37, 38, 39]. Here, PTPN11 is linked to psoriasis.