APOE and stroke disorder: The risk and time of incidence for PSCI may be determined and influenced by a variety of factors, with previous studies showing that location of stroke (Rost et al., 2021), stroke severity (Elendu et al., 2023), or genetic preconditioning, such as carrying the APOE4 allele (Rajan et al., 2016), may all play a role in PSCI.