CDH1 and breast ductal adenocarcinoma: Given the invasive nature and poor cohesiveness of LBC tumors, radiation may also serve as an important adjunct for local control. Although LBC tumors tend to respond differently to radiotherapy compared to ductal carcinomas, the addition of radiosensitizers such as platinum compounds may help overcome intrinsic resistance mechanisms driven by E-cadherin loss and associated DNA repair deficiencies [8,9].