Notably, HSP70-mediated signaling pathways—including STAT3 activation—have been implicated in macrophage polarization, driving a phenotypic shift from proinflammatory M1 (marked by CD68) to anti-inflammatory M2 (marked by CD163) states in conditions, such as drug-induced AKI [15, 16]. The gene discussed is STAT3; the disease is acute kidney injury.