Furthermore, ATRA regulates the expression of cell cycle proteins, causing cell cycle arrest at specific stages and suppressing leukemia cell proliferation, research have found that during the development of BPDCN leukemia, MYB switches from a regulator of DC lineage genes to aberrantly regulating G2/M cell cycle control genes. The gene discussed is MYB; the disease is CD4+/CD56+ hematodermic neoplasm.