PPARA and acute kidney injury: Injury to renal tubular epithelial cells is also frequently seen in cisplatin treatment; fatty acid oxidation (FAO) supplies energy to renal tubular epithelial cells, where peroxisome proliferator receptor alpha (PPARα) is a major regulator of FAO (Robbins and Nie, 2012),Melatonin increased PPARα gene and FAO expression and reduced cisplatin-generated acute kidney injury (Li N. et al., 2022).