TWIST1 and lung cancer: Among the regulatory network governing this process, Twist and Snail transcription factors have been identified as pivotal molecular regulators that orchestrate both EMT activation and the dissemination of cancerous cells (Gundamaraju et al., 2022),and have been shown to target Twist to inhibit the EMT of lung cancer cells, thereby effectively controlling lung cancer metastasis (Chao et al., 2019).