BECN1 and breast cancer: melatonin is also involved in the autophagy process of breast cancer cells, D Wu et al. found that significantly increased anti-apoptotic proteins, LC3- ΙΙ/LC3-Ι ratio of autophagy marker LC3, and the expression of Beclin1 when it was used in the induction of autophagy in breast cancer cells through the combination of MLT and autophagy inhibitor 3-MA.