The results indicated that the high PRMT5 expression in RCC patients was significantly linked to a tumor size greater than 7 cm (P = 0.002), a greater invasion depth (P < 0.001), lymph node metastasis (P = 0.005), and distant metastasis (P < 0.001). The gene discussed is PRMT5; the disease is metastatic malignant neoplasm in the lymph nodes.