Proteins binding to CCN5(wt) were enriched in lipid metabolism related terms such as “insulin resistance”, “Cushing syndrome”, “Longevity regulating pathway”, and “response to fatty acid”, while those binding to CCN5(ΔSP) were enriched in terms related to "response to nutrient", “insulin resistance”, and “cellular senescence” (Fig. 7B). This evidence concerns the gene CCN5 and Cushing syndrome.