These patients are immunized via chemically synthesized in vitro peptide sequences that are either unique to tumors or highly expressed in tumors.163 Therapeutic cancer peptide vaccines fall into two primary categories: synthetic long peptides (approximately 25–30 amino acids) and minimum peptide epitopes (approximately 8–11 AAs).164 Without going through an internalization phase, the minimum peptide epitope may connect directly to the I-binding groove of the major histocompatibility complex (MHC). The gene discussed is HLA-C; the disease is cancer.