RNF144B and polycystic ovary syndrome: Through multi-dimensional bioinformatics interrogation integrating TCGA-OV, GSE140082, and GSE34526 datasets-encompassing differential transcriptomics, prognostic Cox modeling, pathway topology mapping, PPI network deconvolution, survival meta-analysis, and immunoblot validation, we identified RNF144B as a molecular nexus bridging polycystic ovary syndrome (PCOS) and ovarian carcinogenesis within a shared pathological continuum [31].