The mechanism underlying this phenomenon has been investigated to some extent, including gastric cancer, HCC, breast cancer, and leukemia, which are regulated by RNF144-mediated ubiquitination, and the degradation of p53 and LIN28B in ovarian cancer, which is also supposed to be RNF144-mediated ubiquitination, which needs to be further verified. The gene discussed is LIN28B; the disease is breast carcinoma.