Despite both capsules and patches can improve cognition and behaviour oral formulations may have greater effects.123 The evidence for donepezil is conflicting,142 but discontinuation of acetylcholinesterase inhibitors in PDD may worsen clinical outcomes.57 There is insufficient evidence for memantine with conflicting results of various randomised controlled trials.57 Moreover, there is no clear evidence that neuromodulator treatments are useful for PD patients with MCI or dementia.57 Here, ACHE is linked to Parkinson disease.