By overlapping the top 20 most important genes from both the IDD and DM groups, we identified PRTN3, TCN1, CAMP, LMNB1, LRRK2, MNDA, and PHC2 as conserved, disease-shared genes with potential as hub diagnostic biomarkers (Figure 4E). This evidence concerns the gene LMNB1 and intervertebral disk degenerative disorder.