Critical genes in the cancer and cellular senescence, encompassing elevated expression of CXCL8, GADD45, jun proto-oncogene (JUN, FC = 1.3, adjusted P-value = 3.2e−13), and laminin beta 3 (LAMB3, FC = 1.4, adjusted P-value = 6.6e−11), as well as decreased tyrosine-kinase receptor G (KITG, FC = −0.57, adjusted P-value = 3.1e−06), retinoid X receptor alpha (RXRA, FC = −0.57, adjusted P-value = 1.4e−05), and axis inhibition protein 2 (AXIN2, FC = −0.93, adjusted P-value = 2.0e−05) (Figure 4E, Supplementary Figure S3b). The gene discussed is GADD45A; the disease is cancer.