H1 binding was observed to be similar between healthy donors (median 4.7 range 22.4%) and breast cancer patients (median 5.7 range 35.5%) (Figure 3E), where H1 positive signal was mostly observed on CD45RO+ memory cells in both CD8 positive and negative cell populations (Figure 3F and Figure S5C). The gene discussed is CD8A; the disease is breast carcinoma.