We previously found that cysteine at position 674 (C674) is a key glutathionylation site that regulates SERCA2 activity, and the irreversible oxidation of SERCA2 C674 is involved in atherosclerosis, aortic aneurysm and pulmonary hypertension 5-7. The gene discussed is ATP2A2; the disease is pulmonary arterial hypertension.