Moreover, infiltrating CD4+ T and CD8+ T cells in mouse PDAC models displayed activated IL-10 promoter and repressed T-bet activity (IL-10high/IFN-γlow, PD-1high phenotype), whereas the infiltrating T cells in TAM-inhibited mouse tumor models exhibited reduced IL-10 and PD-1 levels and activated T-bet promoter activity (IL-10low/IFN-γhigh, PD-1low phenotype), suggesting the epigenetic modulation of infiltrating T cells by TAMs 96. This evidence concerns the gene CD8A and neoplasm.