RBFOX3 and Alzheimer disease: Immunofluorescence analysis results further showed that Mn3O4 nanozymes significantly increased the NeuN-positive area of prefrontal cortical neurons (p < 0.001, Figure 4F-G) and significantly reduced the positive area of fAβ plaques (p < 0.0001, Figure 4H-I), demonstrating its efficacy in improving AD pathology.