APOA1 and neoplasm: Wang et al. constructed a ROS/pH/NIR triple-responsive nanoassembly (siSnailaRGODox) by combining PBA-crosslinked short-chain polyquaternium (RCSP) with a graphene oxide (GO) scaffold, which was further modified with apolipoprotein A-I (apoA-I) for the dual-targeted modulation of tumor cells and M2 TAMs (Figure 15).