Firstly, we demonstrated the successful establishment of this cisplatin-induced POF mouse model through body weight, ovary weight, ovary weight/ body weight (Figure S2A-D), the estrous cycle (Figure S2E-F) and serum sex hormone including E2, FSH, and LH (Figure S2G-I), HE staining and follicle counting (Figure S2J-L). The gene discussed is BRD2; the disease is premature menopause.