We utilized the peritumor tissues of patients with CRC to evaluate the effect of HIF-2α/CXCL12/CXCR4/CD163 in the clinic and found that these molecules were expressed higher in the peritumor tissues of CRC patients with local recurrence (P1) than in those without local recurrence (P2) (Figure 8A), indicating their roles in promoting invasion. The gene discussed is EPAS1; the disease is colorectal carcinoma.