Furthermore, the infiltration of F4/80+ macrophages, M2 and CXCR4+ macrophages in peritumor intestine, which was stimulated by HIF2A-overexpressed exosome, was also significantly decreased (Figure 7F and G), as was the attenuation of tumor cell infiltration (Figure 7H). The gene discussed is CXCR4; the disease is neoplasm.