FLT3 and acute myeloid leukemia: Recently reported preclinical results showed that inhibition of another TCA cycle enzyme, the succinyl dehydrogenase (SDH, ETC complex II), using inhibitors such as thenoyltrifluoroacetone (TTFA) or 3-nitropropionic acid (3-NPA) combined with MCT1 lactate transporter inhibition by α-cyano-4-hydroxycinnamate (CHC) or AZD3965 impaired leukemogenesis in FLT3-ITD mutated AML models in vitro and in vivo [113], warranting further investigation.