GNAS and major depressive disorder: After 6 weeks of ADT, the mean Gsα biomarker response increased from 1.36 ±0.16 to 2.77 ±0.98 (>100% increase) in these five subjects in contrast to 3.52 ±0.14 to 3.89 0.14 (10% increase) in the MDD subjects with screen Gsα biomarker responses >1.5 (Mann–Whitney U test; na= 14, nb= 5; z= −2.50 p= 0.012; effect size= 0.55).