GNAS and major depressive disorder: After 6 weeks of ADT, the mean percentage increase of Gsα biomarker responses was significantly greater in the MDD subjects with Gsα marker values<1.8 at screen compared with subjects with values >1.8 (Mann–Whitney U test; na= 11, nb= 8; z= −2.91; p= 0.004; effect size= 0.63).