Subsequent MR analysis on these three core sepsis genes a significant positive relationship with sepsis for all three genes on sepsis based on the IVW method: LRPAP1 (OR=1.104; 95% CI: [1.023~1.192]; P = 0.011), NTSR1 (OR=1.075; 95% CI: [1.009~1.145]; P = 0.025), and SEMA4A (OR=1.062; 95% CI: [1.009~1.118]; P = 0.022) (Figure 1F). This evidence concerns the gene SEMA4A and Sepsis.