While the low expression group of SEMA4A exhibited active GO biological functions and pathways such as cytosolic ribosome, large ribosomal subunit, ribosomal subunit, ribosome, and structural constituent of ribosome, along with KEGG pathways like allograft rejection, autoimmune thyroid disease, graft versus host disease, ribosome, and type I diabetes mellitus. Here, SEMA4A is linked to graft versus host disease.