Some scholars have evaluated 17 biomarkers in the serum of patients with CD colitis, and logistic regression analysis shows that, IL-6, Procalcitonin, IL-8, IL-2R, and hepatocyte growth factor are significantly correlated with adverse outcomes of CDI (13), but the validation of biomarkers related to rCDI was still relatively lacking. Here, IL6 is linked to clostridium difficile infection.