The comparison of whole blood responses between T1DM and controls included three sets of immune stimuli: (i) microspheres (Int G, High G, SA/A 10/90, SA/A 20/80, and AP), (ii) bacterial/fungal bioparticles (HKEB, HKSP, HKMT and HKCA) and (iii) selective agonists targeting distinct immune sensors (various TLR ligands, a STING ligand, and a polyclonal T cell activator). Here, STING1 is linked to type 1 diabetes mellitus.